As well as providing a bespoke service to customers and problem solving consultancy Alcyomics can provide a range of services associated with immune-monitoring and immune investigation.

These include:

• T cell proliferation and cytokine responses in one assay as well as histopathology/ toxicology read out


• Cytokine multiplex assays eg via Luminex, FACS, ELISA, ELISPOT;


• Whole blood cytokine assays


• Peripheral blood mononuclear cell subset analysis including DC and NK subsets and intracellular staining


• T regulatory cell analysis including inhibition assays, phenotype ( FoxP3 via RT - PCR and FACS analysis)


• Blood cell subset, serum and plasma isolation, and cryopreservation


• Cell subset isolation via magnetic beads


• DNA and RNA extraction


• mRNA and micro RNA  analysis on cells and tissue


• Immunohistochemistry


• Assessment of immune suppressant activity of new immunomodulators


• Offers the opportunity to minimise risk by evaluating drug candidates in vitro at an earlier stage, thus lowering drug development costs prior to clinical trials


• Investigates mode of action, e.g. cytokine response, and target identification, including mRNA analysis, aiding in drug discovery


• Detect adverse reactions to novel compounds e.g. immunogenicity, allergy or hypersensitivity


• Screening - up to 30 compounds in one test assay


• Discrimination between sensitiser versus non sensitiser and allergen versus non allergen in one test


• Potency assay on selected compounds including monoclonal antibodies